What Is So Fascinating About Historical Geography Research Paper Topics?

<h1> What Is So Fascinating About Historical Geography Research Paper Topics? </h1> <h2> The Basics of Historical Geography Research Paper Topics</h2> <p>Geography is a charming subject. Monetary geology has a broad family. It identifies with the investigation of monetary exercises as for geographic terms. Basic monetary geology is the last subject of study. </p> <p>You may be thinking about how you're ready to compose the exploration proposition results at whatever point you haven't really directed the examination yet. By finding the right research questions, you will persuade the crowd of the hugeness of your exploration. In this segment, you're discover look into proposition subjects in numerous remarkable areas. You've looked to a great extent to find an adequate point for investigate yet the entirety of your endeavors have gone futile. </p> <h2> New Step by Step Roadmap for Historical Geography Research Paper Topics</h2> <p>Hence, in the event that you think banking papers are exhausting simply like your association considers are, at that point you're presumably off-base here. Banking articles can be genuine amusing to play with in the event that you have a comprehensive comprehension about the train and have unmistakable fascination for composing, so should you trust you can't compose OK banking expositions than again you're off base. Step by step instructions to get a PC paper. </p> <p>Bear as a top priority, in case you're composing a contention about whether they truly existed, you're need to introduce proof to back up your contention however will likewise should manage the counterargument. The secret to composing a powerful exposition is superb readiness. Composing a research paper in topography is a fairly captivating activity. The equivalent is valid for writing.</p> <p>Quora in Geography yet don't see how to decide on a Here are two or three subjects for you which will assist you with acknowledging how to make your theme 1. The whole research ought to be developed around or from this issue. Regardless of whether a specific research paper subject is getting heaps of buzz as of now or others appear to be keen on expounding on it, don't feel enticed to make it your theme on the off chance that you don't truly have an enthusiasm for it too. In the event that you might want to have a solid theme for your exploration paper then you ought to hav e several things in your musings. </p> <p>It is conceivable to give instances of the theme which is being examined. At the point when you've picked your theme, endeavor to make your title appealing and significant. You should be sure to comprehend everything obviously once you select an exposition theme. An unpredictable research paper theme won't just take part of time however what's more probably won't be effectively fathomable because of its multifaceted nature. </p> <h2> The Most Popular Historical Geography Research Paper Topics </h2> <p>Writing an exploration paper despite the fact that may seem testing is an extensive part of typical understudy life. Decide on a school inquire about paper subject which you're familiar with or like research on. Best research paper theme is one which can be sponsored up with adequate proof. Perfect school explore paper subjects are the ones which are unique. </p> <p>Writing an examination paper in Geography can be a harsh undertaking since the entirety of the information you use must be legitimate, verified, and later. Research paper assessors love thoughts which give something new or go over a novel and propelled thought. On the off chance that you have any polls for your examination proposition or some different archives connected to your examination, remember every one of them for the indeces. Understudies meet with their preceptors in any event one time each quarter to go over their program and offer data on their advancement. </p> <p>Now you realize how to structure an exploration proposition, it's a great opportunity to begin the activity. As an outcome, the examination will help in deciding the manner in which the plastic waste should be possible away with so as to stop the event of their belongings. 1 day it could be precisely the same in the US yet starting at now there is really no sign of progress not far off. Cla rify the key issue you have to investigate and explain why it's basic. </p>

Bioethics Essay Topics

<h1>Bioethics Essay Topics</h1><p>If you are searching for exposition subjects that think about to being a balanced individual, at that point you might need to consider bioethics article themes. They will assist you with finding out about your own character and the qualities that characterize it.</p><p></p><p>Bioethics exposition themes are regularly partitioned into three classes, the first is the general classification. This is the class that incorporates themes like the meaning of death, barrenness, sexual direction, opportunity, freedom, and religion. These subjects are commonly the most broad and will be utilized in most courses.</p><p></p><p>Essay points that emphasis on a particular part of one's life can likewise be found in this class. For instance, on the off chance that you are keen on a theme like killing, you will discover numerous that remember the point for their articles. The principle motivation behind such subjects is to investigate an incredible impacts on others and other people.</p><p></p><p>You may likewise locate that many exposition points depend on the idea of morals. Most ordinarily, this includes moral issues and what our gauges are as far as lead and ethics. This can help with your contention that you have created and used to decide the correct thing to do.</p><p></p><p>In expansion to these general themes, you will likewise discover increasingly explicit bioethics article subjects. For instance, one of the themes that has been around for quite a while is passing. Demise has been a hot catch for quite a while and is usually utilized in numerous bioethics essays.</p><p></p><p>Other themes that are explicitly identified with death can likewise incorporate the encounters that one has had while biting the dust. You will discover points that spread the way toward passing on, managing a terminal disease, or managing end of life issues. By looking at such things as these, youwill increase a superior comprehension of what demise intends to you.</p><p></p><p>When it comes to exposition points that include a more elevated level of information, you will locate that the greater part of them include hypothesis and reasoning. These are the themes that you will discover in a portion of the courses that you take. This incorporates morals courses.</p><p></p><p>Remember that your objectives when searching for bioethics paper subjects are to get something out of them that you can utilize later on. While you can utilize these subjects to increase a comprehension of yourself, they may not assist you with different aspects of your life. You ought to likewise be mindful so as to discover something that will likewise be utilized in your classes.</p>

College Essay Grading - Dont Get Cheap Quality College Essays

College Essay Grading - Don't Get Cheap Quality College EssaysA lot of essays are graded by the college instructors, and a lot of times there is no formal process for this. Usually the college administrators will ask their students to grade their college essays themselves. But this can be a very risky thing to do. The professors could have two reasons for grading a certain essay.The first reason is that he or she will want to see how well the student can compose an essay on his or her own, without using any kind of professional opinion. This means that the essay will only be graded if it is written by someone who knows exactly what he or she is doing, and what to do with a college essay.The second reason is that the professor wants to see if the student really thinks like a professional writer. In other words, does the student think like an English professor. And if the student writes like a professor, the professor is more likely to give him or her a higher grade, regardless of how the student actually goes about writing.In such cases, the students have to realize that the teacher might be biased, and they need to be careful. Moreover, the student has to make sure that he or she doesn't do anything that could hurt his or her grade.If you need to get your college essay graded by an expert in this area, you can use the internet to help you out. You can look for websites that offer college essay review services and see what kind of grade that they give the students.You must know that you will not always get a perfect score if you choose to use the services offered by the websites. It is for this reason that you must pay attention to the details that are listed on the website.You must realize that the college essay that you write is a big thing, and it will affect the future of your career. That is why you must make sure that you should only hire a service that can offer you a high grade, but not at the expense of lowering your grade. Since it is hard to give a hi gh grade, a cheap service could be much worse.Remember that even if you don't need to use the services offered by the local college essay grading services, you can still look for them online. The reviews you get online will help you a lot in deciding which company to use.

Essay Topics: How to Write an Essay With Essays As Its Topic

Essay Topics: How to Write an Essay With Essays As Its TopicThomas Paine has written essays on history, contemporary issues, contemporary politics, the class system, the health care industry, and so on. Nowadays, his essays are included in the body of the Humanities essay course. It is not surprising, because Thomas Paine has written some of the best essays on those subjects of study that have received critical acclaim. This essay may also be found online as well.Big news is everywhere, especially in this day and age. Unfortunately, this also includes careless and insensitive writing. This is not to say that writing would be less effective if it was more sophisticated. Sometimes simplicity and directness are the best choices. In this article, I will attempt to answer the question posed in the title.Well, since students are asked to write a thesis paper in college and a thesis paper includes essays as its topic, why would any writer think that a thesis paper with essays as its topic i s any different from a thesis paper without essays? This is a good question because the vast majority of first-year college students are expected to write a thesis paper. Many of them are expected to write one that is extremely long and very technical, which leads me to my second question:Would writing essays for the project to be as easy or difficult as writing a thesis? This is a question that every college student should ask themselves when writing a thesis. It can be a daunting task, especially when a thesis can be quite complex.Not all student's mind this way, but there are many who are influenced by these ideas. The truth is that, writing a thesis is not as hard as many assume. The reality is that writing a thesis is often as easy as writing an essay, since they are essentially the same thing.Most professors have rigidly set expectations for their students. A thesis is just like writing an essay. It asks the student to generate a body of evidence to support their argument and then to present their findings.That said, there are things you can do in order to better prepare yourself for writing a thesis. Some of these are discussed in this article.

Art of the Ages Essay - 736 Words

nbsp;nbsp;nbsp;nbsp;nbsp;The main focus of art from the Early Middle Ages to the Renaissance period involved fundamental changes in the way individuals viewed their world. A central element of the Renaissance was the rediscovery of ancient world of Greece and Rome. The ancient classics of philosophy, literature, and science inspired the development of empirical methods to pursue studies in these fields. As Europeans became increasingly aware of classical knowledge some like Galileo began to build on that knowledge actual observation and study of the natural world, even conceiving experiments to test his theories. It is art, however, that is the most visible indication of the changing outlook of Europeans. The focus on the natural†¦show more content†¦His task was to Glorify God along guidelines clearly established by the Church. The Renaissance artist was a very different individual. He was much more than a craftsman. He was a creator. He was viewed differently than the mere artisan artists were viewed in the Medieval era. The Renaissance artist was greatly respected in a world still dominated by the aristocracy. Both the aristocracy and the Church and later in the Medieval era wealthy merchants began respecting the artist not only for his technical prowess, but also for his creative powers and imagination--in fact a new development in Western art. The artist was seen as an individual whose personal aesthetic expression was of importance. The artistic style changed dramatically from the Early Middle Ages to the Renaissance period. The Renaissance period will always be closely associated with achievements in literature, art, and music. In painting, sculpture, and architecture the Renaissance tended to break with medieval traditions. Renaissance painters turned from the purely religious subjects of the Middle Ages to a depiction of the natural world. Technical advances in the representation of perspective, anatomy, and light and shadow were matched by a great expansion in subject matter. Portraits, studies of the human form, animals, landscapes, scenes of daily life, and historic events all joined religious subjects as acceptable material for the painter. Painting and sculpture were no longer consideredShow MoreRelatedThe Art Of The Middle Age897 Words   |  4 PagesThe Museum in the Middle Age During the Middle Age when governed by Christianity, the churches and monasteries played a role as a treasure storage for collections and exhibitions of precious goods. Even the most of collected and produced objects or art works were the tools for religious ceremony and the ornaments for the interior and exterior of church. The churches used a collection and display of precious goods in a way to attracts the publics to the church unlike that artworks were given secularRead MoreArt During The Middle Ages1243 Words   |  5 Pages Art during the Italian Renaissance differed from art during the Middle Ages. The two have contrasting characteristics and concepts. In the Middle Ages the subject of almost all European art was religion, specifically. Although Renaissance artists continued to paint religious paintings and portraits of individuals, they also focused on the details of everyday life. They also used new techniques such as sfumato, chiaroscuro and perspective. The artists of the Italian Renaissance expressed the idealsRead MoreArt Form for the Digital Age864 Words   |  4 PagesArt Form For The Digital Age Summary â€Å"Art Form For The Digital Age,† by Henry Jenkins is about gaming expanding and how its being considered a digital art. The growing game industry is said to be the most growing form of art in the economy today. The gaming industry has grown tremendously in the past century. It went from silent pong games to intense story plot and mind blowing real life graphics like Final Fantasy. Games are becoming more and more realistic, characters can talk, andRead MoreThe Middle Ages: Art and Religion578 Words   |  2 PagesThe Middle Ages: Art and Religion Religion and art have gone hand in hand for thousands of years. Almost every religious organization makes use of it. It idealizes, glorifies, protests, and tells the messages of religion. During some time periods of out history are existed for the sake of faiths. Artists of our time are generally free to create and make statements on anything they want. People, nature, colors, or ambitions might be just as intriguing to an artist as the visual aspect of a crucifixionRead MoreThe Work Of Art And The Age Of Mechanical Reproduction911 Words   |  4 PagesIn the piece â€Å"The Work of Art in the Age of Mechanical Reproduction,† Benjamin tackles the evolution of reproduction coinciding with the introduction advanced technologies; and how art, specifically film, has transformed since this introduction. He asserts that reproduction has now become part of the process in art because of mediums like film and photography, however their reliance on technology creates less authenticity among art forms due to less of the original art still be connected to the pieceRead MoreThe Work Of Art And The Age Of Mechanical Reproduction1320 Words   |  6 Pagesessay, â€Å"The Work of Art in the Age of Mechanical Reproduction† by briefly distinguishing his categories from traditional aesthetic values, those of â€Å"creativity and genius, eternal value and mystery† (Benjamin, 218). In contrast, he relates these tendencies to bourgeois and fascist ideologies and to the conditions, inevitably generated out of capitalism itself, which provoke â€Å"revolutionary demands in the politics of art† (217-8) Benjamin claims that in times past the role of art has been to provideRead More Art in the Age of Mechanical Reproduction Essay3126 Words   |  13 PagesVisit any major museum of art, at any given time, and one could find an abundance of monumental names listed on tiny plaques hanging next to even more recognizable works of art. The excitement felt by any art enthusiast when walking into these buildings of time and creation, is undeniable and especially unique. Could it be the atmosphere of the building, the presence of artwork, the people, possibly the grandeur of the space, or perhaps, could it be the spirit of the artists themselves, peeringRead MoreThe Tang Dynasty : The Classical Age Of Art1070 Words   |  5 Pages The Tang dynasty was retroactively viewed as the classical age of art. Later generations would try to return to the styles displayed during this era. The earliest variations of shanshui paintings (literally translated as mountain-water) emerged at this time . Figurative drawing was stronger during this dynasty in a way than it ever would be again. These drawings often fell under the style of gong-bi (literally meaning â€Å"meticulous†) which were highly detailed, often brightly colored narrativesRead MoreThe Work Of Art And The Age Of Mechanical Reproduction1180 Words   |  5 Pagesthere is a new dev elopment in media that â€Å"will change our lives†. Instagram, Facebook, Twitter, are all forms of mass media, but one could dispute that they are unnecessary to the development of society. Walter Benjamin argues in, â€Å"The Work of Art in the Age of Mechanical Reproduction,† that with reproducibility of images, submission towards the film increases thus a lack in the formation of one’s own opinions. Today, if asked, not many would protest the invention and rise of film, but according toRead MoreArt and Architecture in the Middle Ages and Renaissance Essay949 Words   |  4 PagesThe difference between the Middle Ages and the Renaissance is most visible through art and architecture, demonstrated specifically through an emphasis on religion or classical antiquity, and humanity. During the Middle Ages, art was more religious because it had a very religious influence from the church having such great power in the community. When the Renaissance started, art b ecame more focused on ancient Greece. The Greek influence was because scholars were broadly studying the revival of classical

Thirty Minutes Later Are You Smarter Yet Free Essays

Each and every night millions upon millions of people turn on their televisions and tune in to their favorite programs. Most people think that this behavior is perfectly normal and that nothing is either exceptionally good or detrimentally bad about doing so. Others actually think that watching television can and sometimes does make you smarter. We will write a custom essay sample on Thirty Minutes Later: Are You Smarter Yet? or any similar topic only for you Order Now I feel that the general statement â€Å"tv makes you smarter† is not specific enough when talking about such an issue. I think that some television programs can help you gain some knowledge but I do not believe that all television makes you smarter. So, does watching television make you smarter, dumber, or does it have no affect at all? In Steven Johnson’s essay â€Å"Watching TV Makes You Smarter† he argues that watching television â€Å"alters the mental development of young people for the better (291)†. Meaning that when young people watch television it can aide in the development of their minds. In a nutshell, he is saying that watching television can actually make a person smarter. In his essay, Johnson uses the popular show 24 to support his claim. He states that â€Å"to make sense of an episode of 24 you have to pay attention, make inferences, and track social relationships†(279). Johnson refers to this as part of what he calls the Sleeper Curve. Johnson believes that the Sleeper Curve is the single most important new force altering the mental development of young people today, and it is largely a force for good†(279). He agrees that the media may indeed contain more negative messages but he doesn’t think that is the only way to evaluate whether our television shows are having a positive impact or not. In one part of his essay, Johnson compares the intellectual strain of watching shows like Frasier, and The Mary Tyler Moore Show to the physical strain of watching Monday Night Football. With that comparison he is basically saying that the viewer doesn’t have to think about the content of the show in order to follow the storyline the same way a person doesn’t have to actually play football in order to enjoy a game. Throughout his essay, Johnson even goes as far as to say that even â€Å"bad† television has gotten better. To validate this point he talks about Joe Millionaire and The Apprentice. He discusses how in order how in order to win the show contestants had to overcome certain obstacles, figure out â€Å"weak spots† in the game, and use everything they learned to complete the last  challenge which usually contained a twist. This goes to say that on the surface it may seem like these shows are easy to follow but they contain surprises that may interrupt what the viewer thought was going to happen. Johnson states that â€Å"traditional narrative also trigger emotional connections to the characters† (291). He explains this by talking about the largely popular show Survivor, and how because our emotions are involved it becomes easy to vote someone off the island as opposed to someone else. I think that only certain types of television shows makes you smarter, so part of me agrees with Steven Johnson’s argument. I think that people can learn things from certain kinds of shows. When a person watches show on the Food Network, the person will most likely learn how to prepare a new dish, or improve upon a technique that they are having trouble with. Another example would be when children watch â€Å"Dora the Explorer†. Some people might only see a show like this as way to keep children quiet and occupied. What they would realize if they actually sat down and watched an episode or two is that children can earn many things like; shapes, colors, numbers, letters and even some Spanish, all within the thirty minute runtime of the show. There may be some sitcoms or reality shows out there that you can learn from but I have yet to find one that I learned a lesson from. The reason I don’t fully agree with his argument that television makes you smarter is because I think only certain types of shows make you smarter. I think in his essay he is referring to all television shows and genres. I think he is referring to all genres in his argument because he doesn’t say that any specific genre or show is excluded. I don’t think a person can learn anything from a football game, or an episode of Family Guy because, in my opinion, these shows have the sole purpose of entertaining the people that watch them. Family Guy is an animated series about a family and all of the crazy situations they get themselves in to. By the way, one member of the family is a talking baby. In Dana Stevens’ essay, Thinking Outside the Idiot Box, she blatantly disagrees with Johnson. She even goes as far as to mock him saying, â€Å"If watching television really make you smarter, as Steven Johnson argued in an article†¦ then I guess I need to watch a lot more television†¦because†¦I could make no sense of Johnson’s piece†(295). I think this comment used logos because she is saying that since she wasn’t able to understand Johnson’s argument maybe she doesn’t watch enough television. Of course this comment was a sarcastic one. In order to make this point clearer she references the popular children’s show Teletubbies, saying that it is â€Å"essentially a tutorial instructing toddlers the basics of vegging out† (Stevens 296). She thinks that the show 24 teaches you nothing except to watch further episodes of the show. Stevens also states that Johnson’s claim for television as a tool for brain enhancement seems deeply and hilariously bogus (297). So, clearly Stevens is a part of the group of people that do not think television makes you smarter. I don’t think Stevens is totally watching television. I think instead she is against people watching television all the time and thinking it will make them smarter. She thinks that adults should monitor the amount of television they watch, the same way they monitor the number f alcoholic drinks they consume at a bar. Stevens ends her essay by giving readers a way to test Johnson’s theory: â€Å"National Television Turnoff Week† (298). Even if the participant’s IQ doesn’t drop from not watching television, it would still give people’s minds a break from watching television and give them the opportunity to tune back in with real people, real problems, and real life. She also mentions a handheld device that can switch off any television set within twenty to twenty-five feet. The difference between this remote and any other remote already on the market is that this remote would have the ability to control all television sets within its radius. Like with any new technology there are both proponents and opponents. Proponents think that this device will restore peace and calmness to public places such as airports and bus stations. Opponents think this just another way for people to try to control their lives. I think the device is very invasive and controlling. If people want to watch television for twenty-four hours straight, they are adults and they should be able to do that. This device relates to the debate about television because people that think television is watched too much would want this remote to be used. But for people that think television is useful as well as entertaining, the use of this device would seem like an invasion of privacy. I am personally on the fence of this issue. I think some television programs have educational value. I also think people should watch less television, and perhaps pick up a book- which are proven to make you smarter. I think shows such as Wheel of Fortune, Family Feud, and Who Wants to Be a Millionaire make you smarter because you can’t help but immerse yourself in the show and try to get the answers right. Even if you get the answers wrong, or never use the information you gained, you sill learned something. On the other hand, I don’t think reality television shows can teach you anything at all. Think of your favorite reality show, now take a few seconds to make a mental list of the things you have learned from watching that show. If you can think of anything at all, the list is probably very short. This is ok because the sole purpose of television is not to educate people. I think television is supposed to be watched for entertainment purposes. If you were to take a poll of the television shows people watch on a regular basis, most of the answers would probably be; Scandal, Teen Mom, and NCIS. These shows I would have to say contain very little to nothing to teach a person. Some shows can even encourage bad behaviors and influence people to do bad things. Let’s take the popular MTV show Teen Mom for instance; before the show first premiered, when teens would get pregnant they didn’t think it was cool, or cute, and they definitely were not posting pictures on Facebook with their pregnant friends. When teenage girls saw all of the fame the stars of the show were getting, it somehow registered in their minds that if they got pregnant at a young age they would somehow become the star of a show, get paid for it, and live a happy life. What they don’t realize until it’s too late is that most of the stuff on â€Å"reality† shows are staged and fake. One of my personal favorite shows was Jersey Shore, which was a reality show about a group of strangers living in a house together for a number of months. The show followed all of the drinking, smoking, drama, and sex that went on in that house. What young teens seemed to forget was that the people on that show were of legal drinking age that were held accountable for their own actions, so when they went out trying to mimic the cast members behavior they and their parents ended up in trouble. This supports my claim that some television programs are for entertainment purposes because when things are imitated that shouldn’t be the consequences are much worse in real life than they are on the show. I also feel as though the time people spend watching television could be spent doing more productive things such as exercising, working, reading, or having and actual conversation with someone. If people sent half as much time doing things like that as they do watching and recording their favorite shows I think people would be a lot healthier and happier. In my opinion watching television is like a double-edged sword. Watching television sometimes for entertainment purposes is a good way to relax and connect with friends and family. I think the trouble happens when people become consumed with their favorite shows and totally disconnect from the real world. I admit. There have been a few times when I have been doing something and I just dropped everything because I knew the season premiere of my favorite show would be starting son. But some people drop everything for every episode of their favorite show. That kind of behavior can actually hurt relationships because no one wants to be constantly tuned out by a show that will most likely come on multiple times within the next few days. I think until someone does some sort of definitive research on whether or not watching television makes a person smarter, this will be an ongoing debate. Things like remote devices that can control any television aren’t going to change people’s opinions. If anything it will only make them feel angry towards the people trying to control a part of their lives. Television just like anything else in the world has its positive and negative points. I just don’t think one of those positives is making people smarter. How to cite Thirty Minutes Later: Are You Smarter Yet?, Papers

Introduction to Clinical Trial Research

Introduction This is a review and critique of the Wonder Drug Protocol based on its design, objectives, criteria for patient inclusion, study procedures, and safety and efficacy parameters.Advertising We will write a custom research paper sample on Introduction to Clinical Trial Research specifically for you for only $16.05 $11/page Learn More Design Before the beginning of any clinical study, the research team and the sponsor must ensure that several components of the study are in place (World Health Organization, 2002). The study must be accurate and efficient in terms of design. It is imperative to balance all aspects of the business and scientific validity of the trial. The Wonder Drug Protocol used a randomized, double-blind, placebo-controlled, and a parallel group design (Spilker, 2000). The main objective of this study design is to evaluate the safety and efficacy of Wonder Drug in patients who have a mild to moderate severity condition of probab le Alzheimer’s disease (AD). The design aims to demonstrate similar primary and secondary efficacy measurements, which would be the same as those used in other cases of anti-dementia trials. A good clinical trial research design provides objectives of the study design. This protocol has a clear objective for the study. The objective acts or provides guidance on primary and secondary endpoints for assessment during the study. The protocol provides the aim of the clinical trial research at a 5-center phase II. The process involves screening of AD patients followed by a random process of assigning either a placebo or Wonder Drug everyday for 40 weeks, which would consist of 30 doses. The design indicates that half the patient will take placebo and the other half will receive the Wonder Drug. It also shows that the study shall be performed in one, three, and six months after the baseline. This is adequate information that can answer pertinent research questions. However, the prot ocol does not provide any schematic diagram of the study design. The protocol shows the study duration after the baseline and sequences of administering both the placebo and the Wonder Drug. The study design shows the amount of dosage for AD patients, dosing regimen for patients, packaging of the Wonder Drug in 5 mg tablets, and labeling of the drug as scratch off labels for all experimental drugs. It also shows that the drug shall be administered orally. These are requirements in a clinical trial study design, and this protocol clearly captures them.Advertising Looking for research paper on health medicine? Let's see if we can help you! Get your first paper with 15% OFF Learn More It also shows drug storage and accountability, as well as dispense of medication. The protocol insists that the placebo and experimental drug must be stored in a locked cabinet with restricted access. At the same time, the place must have favorable conditions in terms of light and temperatu res. There is also drug accountability during shipment, which requires acknowledgment. This must cover per patient administration and visits before and after the drug return. The Protocol provides follow-ups of adverse events. The study investigators shall follow up all patients who exhibit any adverse cases until the condition ends, becomes medically stable, or until when the patient can no longer be reached for follow-ups. The protocol also shows that all participants who stop the study because of adverse outcomes shall receive medical attention as provided for in the treatment of participants based on the outcome of the study. It will sufficiently document and report all cases for further evaluation. A study design should also indicate when participants should discontinue participation in the trial. For instance, the Wonder Drug Protocol shows that a participant may discontinue the trial in cases of laboratory test abnormalities. In this case, the laboratory outcome may indicate abnormal ranges. Such patients may only continue the study at the discretion of the investigator. Laboratory technicians must monitor outcomes and report to the site in case of adverse results outside the required ranges. The investigator must make decisions that involve the patient continued participation or further tests. The study design also accounts for patient confidentiality. It will adhere to the Declaration of Helsinki and Institutional Review Board (IRB) guidelines. All stakeholders in the study affirm that they shall maintain patient confidentiality, patient’s rights and protect patients against any form of violation. In this study, all patients shall have unique identification numbers and initials of their names for reference purposes. Data analyses shall use a blind technique to protect patients’ identity. In case of any review of participants’ details outside the informed consent, the Protocol recommends a written permission from the participant. T he sponsor and the investigator have recognized serious consequences that concern overlooking of ethical responsibilities in clinical trial research. The study design identifies possible risks and provides steps to mitigating such risks. It has safety, risk, and adverse event provisions. In these cases, outcomes may warrant termination and treatment of participants.Advertising We will write a custom research paper sample on Introduction to Clinical Trial Research specifically for you for only $16.05 $11/page Learn More The protocol also recognizes that death may be an adverse outcome from the trial. Risks may also involve patients’ withdrawal of consents, noncompliance with the protocol, loss of a responsible caregiver to facilitate visits, and in cases where a sponsor terminates the project. The protocol does not provide methods of mitigating all these risks. While clinical trial research may have some benefits to participants in terms of moneta ry compensation or treatment, this study design fails to account for availability or lacks of any benefits to study participants. Sponsors, investigators and other stakeholders should clearly indicate benefits associated with the study trial. Objectives A clinical trial research should have a detailed description of both primary and secondary objectives and purposes of the study. The protocol meets this criterion by providing both primary and secondary objectives of the study trial. The primary objective of the clinical trial research is to assess the efficacy of the â€Å"Wonder drug in improving both the cognition and overall clinical functioning of patients with Alzheimer’s disease† (Darn Good Drug Company, n.d). Further, secondary objectives of the project are to â€Å"study the efficacy of Wonder drug in improving activities of daily living (ADL), and in reducing depressive and behavioral manifestations of Alzheimer’s disease patients† (Darn Good Dru g Company, n.d). However, this protocol does not discuss any issues that relate to the study feasibility. Moreover, there are no details about resources, skills, and experiences of key figures in the study. The protocol also does not indicate any pilot study information prior to this study. Criteria for patient inclusion A good clinical trial study must include participants’ inclusion and exclusion criteria. In most cases, women of childbearing or breastfeeding tend not to take part in several studies. Generally, pregnant women should not take part in clinical trial studies, unless there is a clear reason for including them. Investigators tend to recruit people of different ethnic, racial, and socioeconomic backgrounds to ensure that study benefits are evenly distributed among participants. This study has several inclusion and exclusion criteria to meet unique requirements of the Wonder Drug and placebo.Advertising Looking for research paper on health medicine? Let's see if we can help you! Get your first paper with 15% OFF Learn More The first mandatory inclusion criterion for participants in this study is the informed consent, which both the participant and caregiver must sign before taking part in the study. The study would include women and men aged 50 years and above, and women must be surgically sterile or have two years of post menopause. No pregnant or lactating woman shall take part in the study. There were also specific tests and evaluations, which study participants, had to meet. On exclusion criteria, the study did not include participants with any other critical neurological disease apart from AD. Moreover, investigators excluded alcoholics, substance users, and people with cases of schizophrenia. These procedures were guided by laboratory test outcomes. Clinical trial participants are mainly volunteers. The protocol fails to show whether participants were â€Å"forced, coerced, or enticed into participating by the desire to please one’s doctor, get excess money, or misleading promises of a c ure of an illness† (Medpace Clinical Pharmacology, n.d). These are wrong practices in clinical trials, which do not define a research participant as a volunteer. Volunteers also have the responsibility of ensuring that they satisfy all research entry criteria. This is the inclusion and exclusion criteria in clinical trials. It defines research terms and provides characteristics of people who should or should not take part in the clinical trial. The criteria could include age, weight, disease states, medication, sex, socio-economic background, and allergy among other factors. These selection criteria offer safety to participants and protect the sponsor and investigators against possible lawsuits. It is imperative to note that different clinical trial studies have various inclusion and exclusion criteria for study participants. Study procedures The protocol has study procedures based on different visits during the trial. The initial stage involves a screening visit. The protocol only insists on participants who have passed both inclusion and exclusion criteria and have signed the consent form. During this stage, potential participants take part in different tests, such physical, laboratory, x-ray, blood tests, hematology, and other relevant tests to meet the requirements of the Wonder Drug. Patients must also score required points on the Hamilton Depression Scale. Moreover, this process also accounts for all concomitant medications used within the last 30 days. At this stage, trial participants must also review all study data. The second visit is the procedure for conducting baseline activities, which is scheduled 30 days after baseline screening. Investigators shall randomly give participants their placebo and Wonder Drug at the baseline visit for a period of four weeks on a daily basis (30 doses). Half of the patient would take placebo while the rest would receive the Wonder Drug. The process involves laboratory tests based on the study schedule and vita l signs. Laboratory technicians would observe any changes during these days and record them. The procedure also involves conducting a third visit 35 days after the baseline visit. Investigators must conform to the protocol requirements based on the dates of conducting procedures. The procedure would involve drug return and evaluation of compliance with the protocol. In addition, investigators would also take note of any adverse effects and abnormal variations. Another procedure involves the fourth visit. This happens three months after the baseline visit or with a difference of 14 days earlier or later. This process involves evaluation of abnormal events, variations in concomitant therapy, and participants’ safety assessment. Finally, the fifth visit occurs six months after the baseline visit with a difference of 14 days either earlier or later. The visit must follow the study schedule. It also involves safety evaluation, changes in concomitant therapy, and adverse outcomes. The investigator also notes any changes based on screening outcomes. This is the last visit of the study. The protocol provides a clear study procedure, which other research can duplicate in similar studies. However, this protocol fails to account for follow up visits after the conclusion of the study. Such visits are necessary to encourage many people to participate in later studies. Safety The protocol accounts for safety of research participants by focusing on the vital signs, participant examination, laboratory tests, and other relevant examinations. Safety analysis would involve the comparison of outcomes with baseline values and any changes during the trial period. The study pays specific attention to adverse events (clinically or laboratory) among participants during the study. Hence, any cases of abnormalities are safety concerns to investigators and the sponsor. Moreover, any cases of emerging adverse outcomes shall also be of special interest because these are the main rea sons for several study procedures. The investigator would decide whether patients with safety concerns should continue with the study. For evaluation purposes, there would be records for adverse outcome treatments, type of events, affected body systems, and severity. The protocol also notes that frequencies of treatment for adverse outcomes are necessary for the record. The sponsor shall rely on Safety Monitoring Board (SMB) to conduct safety procedures. This is an independent body, which ensures that all participants in the trial are safe during the study. On this note, one can conclude that the protocol meets safety standards required in a clinical trial study. Efficacy The protocol has both primary and secondary efficacy measurements for the study. The primary efficacy parameter is â€Å"Alzheimer’s Disease Assessment Scale-Cognitive Score (ADAS-COG) while the secondary efficacy parameter is Mini-Mental State Examination (MMSE)† (Darn Good Drug Company, n.d). It pos its that both primary and secondary efficacy measurements would be the same as others used in other anti-dementia studies. In primary efficacy evaluations, the researchers would apply a suitable method for a parallel group with a design that can support several centers. It would involve the normal intent-to-treat evaluation. The process would be random for all participants who were eligible for the study. The study shall also focus on endpoints assessment or last observation available in the case of a patient. The study has a clear efficacy, including primary and secondary analyses with relevant means of conducting subsequent evaluations. Conclusion The Wonder Drug Protocol has a standard clinical trial research. It meets most of the criteria used in such studies. Hence, it is a reliable tool for clinical trial research. It has long inclusion and exclusion criteria to ensure that only eligible participants take part in the study. This ensures safety of participants and reputation of the sponsor and other stakeholders. However, a long list of exclusion and inclusion criteria may present considerable challenges during participant recruitment. Besides, there are no indicated benefits for the study participants, which could discourage many potential participants. The protocol also fails to account for feasibility of the study, any available pilot test, qualifications, skills, and resources required to ensure that the project is successful. References Darn Good Drug Company. (n.d). Protocol. Toronto, Ontario: Darn Good Drug Company. Medpace Clinical Pharmacology. (n.d). Study Participant Information: Participating in Medical Research with Medpace Clinical Pharmacology. Cincinnati, Ohio: Medpace CPU. Spilker, B. (2000). Guide to Clinical Trials. Philadelphia: Raven Press Ltd. World Health Organization. (2002). Handbook for good clinical research practice (GCP): Guidance for implementation. Geneva: WHO the Offi ce of Publications. 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